|
Mutation Information
|
Mutation Site
|
Y63F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
26349829
|
|
Published Year
|
2015 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
|
Author
|
Wang YJ,Lu D,Xu YB,Xing WQ,Tong XK,Wang GF,Feng CL,He PL,Yang L,Tang W,Hu YH,Zuo JP |
|
Evidence
|
To determine whether the activity of 3711 in decreasing HBV RNA encapsidation was related to the presence of the Pol/pgRNA complex, we generated plasmids expressing a Pol deletion mutant and a Pol mutant with a Y63F amino acid substitution which was defective in RT activity but retained RNA binding ability (42).
|
|
|
HBV Mutation Detail Information