HBV Mutation Detail Information

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Mutation Information

Mutation Site	Y63F
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT

Literature Information

PubMed PMID	29669831
Published Year	2018
Journal	Journal of virology
Title	Hepatitis B Virus Core Protein Dephosphorylation Occurs during Pregenomic RNA Encapsidation.
Author	Zhao Q,Hu Z,Cheng J,Wu S,Luo Y,Chang J,Hu J,Guo JT
Evidence	To rigorously determine the phosphorylation status of core proteins in pgRNA-containing capsids, we first established an AML12-derived stable cell line, designated AML12HBVpolY63F, that Tet-inducibly expresses pgRNA encoding Y63F mutant DNA polymerase that is deficient in priming negative-strand DNA synthesis and thus accumulates only pgRNA-containing capsids.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation