HIV Target gene Detail Information

> ABL1 Gene Search Result

Gene Information

Gene Name	ABL1
Gene ID	25
Gene Full Name	ABL proto-oncogene 1, non-receptor tyrosine kinase
Gene Alias	ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; bcr/abl
Transcripts	ENSG00000097007
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P00519
HGNC ID	HGNC:76
VEGA ID	OTTHUMG00000020813
OMIM ID	189980
String ID	9606.ENSP00000361423
Drugbank ID	BE0000014
PharmGKB ID	PA24413
FDA Approved Drug	Blinatumomab;Bosutinib;Busulfan;Dasatinib;Imatinib;Inotuzumab Ozogamicin;Nilotinib;Omacetaxine;Ponatinib;Vincristine

Target gene [ABL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002467	chr9	43	44	6	93	View
4007365	chr9	8	8	4	20	View
4008724	chr9	10	1	3	14	View
4009308	chr9	9	2	1	12	View
4010517	chr9	3	6		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ABL1 expression and immune infiltrating cell level correlation result in HIV+ samples
ABL1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ABL1 expression and immune infiltrating cell level correlation result in HIV+ samples
ABL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).