HIV Target gene Detail Information

> ACTR3 Gene Search Result

Gene Information

Gene Name	ACTR3
Gene ID	10096
Gene Full Name	ARP3 actin related protein 3 homolog
Gene Alias	ARP3
Transcripts	ENSG00000115091
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P61158
HGNC ID	HGNC:170
VEGA ID	OTTHUMG00000153497
OMIM ID	604222
String ID	9606.ENSP00000263238
Drugbank ID	BE0004251
PharmGKB ID	PA24489

Target gene [ACTR3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005459	chr2	32			32	View
4005981	chr2	26	2		28	View
4008082	chr2	16			16	View
4100042	chr2	73	355	189	617	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ACTR3 expression and immune infiltrating cell level correlation result in HIV+ samples
ACTR3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ACTR3 expression and immune infiltrating cell level correlation result in HIV+ samples
ACTR3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).