HIV Target gene Detail Information

> APAF1 Gene Search Result

Gene Information

Gene Name	APAF1
Gene ID	317
Gene Full Name	apoptotic peptidase activating factor 1
Gene Alias	CED4; APAF-1
Transcripts	ENSG00000120868
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Golgi apparatus;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O14727
HGNC ID	HGNC:576
VEGA ID	OTTHUMG00000170214
OMIM ID	602233
String ID	9606.ENSP00000448165
Drugbank ID	BE0000310
PharmGKB ID	PA24868

Target gene [APAF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003880	chr12	53			53	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of APAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
APAF1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of APAF1 expression and immune infiltrating cell level correlation result in HIV+ samples
APAF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).