HIV Target gene Detail Information

> APOBEC3C Gene Search Result

Gene Information

Gene Name	APOBEC3C
Gene ID	27350
Gene Full Name	apolipoprotein B mRNA editing enzyme catalytic subunit 3C
Gene Alias	A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
Transcripts	ENSG00000244509
Virus	HIV
Gene Type	protein coding
HPA Location Info	Intermediate filaments;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9NRW3
HGNC ID	HGNC:17353
VEGA ID	OTTHUMG00000151087
OMIM ID	607750
String ID	9606.ENSP00000355340
PharmGKB ID	PA24893

Target gene [APOBEC3C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000400	chr22	477	14		491	View
4003476	chr22	53	7		60	View
4009081	chr22	13			13	View
4009082	chr22	13			13	View
4009083	chr22	13			13	View
4009084	chr22	13			13	View
4009085	chr22	13			13	View
4009086	chr22	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of APOBEC3C expression and immune infiltrating cell level correlation result in HIV+ samples
APOBEC3C expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of APOBEC3C expression and immune infiltrating cell level correlation result in HIV+ samples
APOBEC3C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).