HTLV1 Target gene Detail Information

> BCL6B Gene Search Result

Gene Information

Gene Name	BCL6B
Gene ID	255877
Gene Full Name	BCL6B, transcription repressor
Gene Alias	BAZF; ZNF62; ZBTB28
Transcripts	ENSG00000161940
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q8N143
HGNC ID	HGNC:1002
VEGA ID	OTTHUMG00000177882
OMIM ID	608992
String ID	9606.ENSP00000293805
PharmGKB ID	PA25313

Target gene [BCL6B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004434	chr17	72	44		116	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of BCL6B expression and immune infiltrating cell level correlation result in HTLV1+ samples
BCL6B expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of BCL6B expression and immune infiltrating cell level correlation result in HTLV1+ samples
BCL6B expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of BCL6B expression and immune infiltrating cell level correlation result in HTLV1+ samples
BCL6B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).