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HBV Target gene Detail Information

> BRAF Gene Search Result


Gene Information
Gene Name BRAF
Gene ID 673
Gene Full Name B-Raf proto-oncogene, serine/threonine kinase
Gene Alias NS7; B-raf; BRAF1; RAFB1; B-RAF1
Transcripts ENSG00000157764
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Gene Function Oncogene
Uniport_ID P15056
HGNC ID HGNC:1097
VEGA ID OTTHUMG00000157457
OMIM ID 164757
String ID 9606.ENSP00000288602
Drugbank ID BE0000634
Drug (Cytoscape Annotation) Regorafenib;Sorafenib Tosylate;Dasatinib;Pazopanib Hydrochloride;Nilotinib;Dabrafenib;Vemurafenib
PharmGKB ID PA25408
FDA Approved Drug Vemurafenib;Dabrafenib;Encorafenib;Atezolizumab;Binimetinib;Cobimetinib;Nivolumab;Pembrolizumab;Trametinib
Target gene [BRAF] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1012915 chr7 4 1 1 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of BRAF expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
BRAF expression: Low -> High
Lollipop of BRAF expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of BRAF expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of BRAF expression and immune infiltrating cell level correlation result in HBV+ samples
BRAF expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).