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HTLV1 Target gene Detail Information

> CAD Gene Search Result


Gene Information
Gene Name CAD
Gene ID 790
Gene Full Name carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Gene Alias CDG1Z; GATD4; EIEE50
Transcripts ENSG00000084774
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID P27708
HGNC ID HGNC:1424
VEGA ID OTTHUMG00000097070
OMIM ID 114010
String ID 9606.ENSP00000264705
Drugbank ID BE0002227
PharmGKB ID PA26023
Target gene [CAD] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004484 chr2 89 21 2 112 View
6015625 chr9 12 2 14 View
6021210 chr9 4 2 6 View
6029766 chr9 1 1 View
6029930 chr9 1 1 View
6030663 chr9 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CAD expression and immune infiltrating cell level correlation result in HTLV1+ samples
CAD expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CAD expression and immune infiltrating cell level correlation result in HTLV1+ samples
CAD expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CAD expression and immune infiltrating cell level correlation result in HTLV1+ samples
CAD expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).