HIV Target gene Detail Information

> CBL Gene Search Result

Gene Information

Gene Name	CBL
Gene ID	867
Gene Full Name	Cbl proto-oncogene
Gene Alias	CBL2; NSLL; C-CBL; RNF55; FRA11B
Transcripts	ENSG00000110395
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P22681
HGNC ID	HGNC:1541
VEGA ID	OTTHUMG00000166170
OMIM ID	165360
String ID	9606.ENSP00000264033
PharmGKB ID	PA26115

Target gene [CBL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000810	chr11	271	4		275	View
4001276	chr11	123	45	16	184	View
4001862	chr11	82	44		126	View
4002742	chr11	73	6	3	82	View
4003250	chr11	56	8	1	65	View
4003796	chr11	12	30	12	54	View
4003804	chr11	43	9	2	54	View
4003839	chr11	50	2	1	53	View
4005353	chr11	31	2		33	View
4007182	chr11	19	1		20	View
4008134	chr11	14	1	1	16	View
4009008	chr11		13		13	View
4009213	chr11	1		11	12	View
4009296	chr11	11		1	12	View
4010176	chr11	5	2	2	9	View
4012206	chr11			5	5	View
4014345	chr11		2		2	View
4015235	chr11	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CBL expression and immune infiltrating cell level correlation result in HIV+ samples
CBL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CBL expression and immune infiltrating cell level correlation result in HIV+ samples
CBL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).