HBV Target gene Detail Information

> CCDC57 Gene Search Result

Gene Information

Gene Name	CCDC57
Gene ID	284001
Gene Full Name	coiled-coil domain containing 57
Transcripts	ENSG00000176155
Virus	HBV
Gene Type	protein coding
HPA Location Info	Microtubules;Centriolar satellite;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q2TAC2
HGNC ID	HGNC:27564
VEGA ID	OTTHUMG00000140396
String ID	9606.ENSP00000374292
PharmGKB ID	PA142672173

Target gene [CCDC57] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001093	chr17	35	801	235	1071	View
1005195	chr17	51	8		59	View
1006865	chr17	30	3		33	View
1006866	chr17	31	2		33	View
1008352	chr17	18	2	1	21	View
1400202	chr17	934	23	9	966	View
1400203	chr17	15	343	18	376	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of CCDC57 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CCDC57 expression: Low -> High
Lollipop of CCDC57 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of CCDC57 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of CCDC57 expression and immune infiltrating cell level correlation result in HBV+ samples
CCDC57 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).