HIV Target gene Detail Information

> CD3E Gene Search Result

Gene Information

Gene Name	CD3E
Gene ID	916
Gene Full Name	CD3e molecule
Gene Alias	T3E; TCRE; IMD18
Transcripts	ENSG00000198851
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins
Uniport_ID	P07766
HGNC ID	HGNC:1674
VEGA ID	OTTHUMG00000166968
OMIM ID	186830
String ID	9606.ENSP00000354566
Drugbank ID	BE0000274
PharmGKB ID	PA26216

Target gene [CD3E] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003386	chr11	21	41		62	View
4005198	chr11	12	23		35	View
4014132	chr11	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of CD3E expression and immune infiltrating cell level correlation result in HIV+ samples
CD3E expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of CD3E expression and immune infiltrating cell level correlation result in HIV+ samples
CD3E expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).