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HTLV1 Target gene Detail Information

> CD81 Gene Search Result


Gene Information
Gene Name CD81
Gene ID 975
Gene Full Name CD81 molecule
Gene Alias S5.7; CVID6; TAPA1; TSPAN28
Transcripts ENSG00000110651
Virus HTLV1
Gene Type protein coding
HPA Location Info Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info CD markers, Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID P60033
HGNC ID HGNC:1701
VEGA ID OTTHUMG00000009892
OMIM ID 186845
String ID 9606.ENSP00000263645
PharmGKB ID PA26240
Target gene [CD81] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001955 chr11 307 3 310 View
6003945 chr11 107 27 1 135 View
6030922 chr11 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CD81 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD81 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CD81 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD81 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CD81 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CD81 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).