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HBV Target gene Detail Information

> CD86 Gene Search Result


Gene Information
Gene Name CD86
Gene ID 942
Gene Full Name CD86 molecule
Gene Alias B70; B7-2; B7.2; LAB72; CD28LG2
Transcripts ENSG00000114013
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P42081
HGNC ID HGNC:1705
VEGA ID OTTHUMG00000159482
OMIM ID 601020
String ID 9606.ENSP00000332049
Drugbank ID BE0000846
PharmGKB ID PA26243
Target gene [CD86] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007519 chr3 13 13 26 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of CD86 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
CD86 expression: Low -> High
Lollipop of CD86 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of CD86 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of CD86 expression and immune infiltrating cell level correlation result in HBV+ samples
CD86 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).