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HTLV1 Target gene Detail Information

> CR2 Gene Search Result


Gene Information
Gene Name CR2
Gene ID 1380
Gene Full Name complement C3d receptor 2
Gene Alias CR; C3DR; CD21; CVID7; SLEB9
Transcripts ENSG00000117322
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info CD markers, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P20023
HGNC ID HGNC:2336
VEGA ID OTTHUMG00000036307
OMIM ID 120650
String ID 9606.ENSP00000356024
PharmGKB ID PA26857
Target gene [CR2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002289 chr6 137 54 68 259 View
6004089 chr5 86 13 29 128 View
6005600 chr22 82 2 84 View
6005601 chr22 82 2 84 View
6006214 chr6 72 1 73 View
6006545 chr22 29 24 14 67 View
6007157 chr22 50 8 1 59 View
6017810 chr22 10 10 View
6023934 chr22 4 4 View
6024136 chr3 3 1 4 View
6028692 chr1 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of CR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CR2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of CR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CR2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of CR2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
CR2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).