HBV Target gene Detail Information

> CYP2C19 Gene Search Result

Gene Information

Gene Name	CYP2C19
Gene ID	1557
Gene Full Name	cytochrome P450 family 2 subfamily C member 19
Gene Alias	CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
Transcripts	ENSG00000165841
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P33261
HGNC ID	HGNC:2621
VEGA ID	OTTHUMG00000018799
OMIM ID	124020
String ID	9606.ENSP00000360372
Drugbank ID	BE0003536
PharmGKB ID	PA124
FDA Approved Drug	Brivaracetam;Carisoprodol;Citalopram;Clobazam;Clopidogrel;Dexlansoprazole;Diazepam;Doxepin;Drospirenone;Ethinyl Estradiol;Escitalopram;Esomeprazole;Flibanserin;Formoterol;Lacosamide;Lansoprazole;Omeprazole;Pantoprazole;Phenytoin;Prasugrel;Rabeprazole;Ticagrelor;Voriconazole

Target gene [CYP2C19] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1017246	chr10		1		1	View
1017565	chr10				0	View
1404582	chr10	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of CYP2C19 expression and immune infiltrating cell level correlation result in HBV+ samples
CYP2C19 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).