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EBV Target gene Detail Information

> DCLK1 Gene Search Result


Gene Information
Gene Name DCLK1
Gene ID 9201
Gene Full Name doublecortin like kinase 1
Gene Alias CL1; DCLK; CLICK1; DCDC3A; DCAMKL1
Transcripts ENSG00000133083
Virus EBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O15075
HGNC ID HGNC:2700
VEGA ID OTTHUMG00000016729
OMIM ID 604742
String ID 9606.ENSP00000255448
Drugbank ID BE0009383
Drug (Cytoscape Annotation) Crizotinib;Sunitinib Malate;Ruxolitinib Phosphate
PharmGKB ID PA162383325
Target gene [DCLK1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3000037 chr13 495 389 49 933 View
3000051 chr13 310 206 19 535 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of DCLK1 expression and immune infiltrating cell level correlation result in EBV+ samples
DCLK1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).