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HPV Target gene Detail Information

> DEGS2 Gene Search Result


Gene Information
Gene Name DEGS2
Gene ID 123099
Gene Full Name delta 4-desaturase, sphingolipid 2
Gene Alias DES2; FADS8; C14orf66
Transcripts ENSG00000168350
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoli;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q6QHC5
HGNC ID HGNC:20113
VEGA ID OTTHUMG00000171537
OMIM ID 610862
String ID 9606.ENSP00000307126
PharmGKB ID PA134973300
Target gene [DEGS2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5300255 chr14 161 21 3 185 View
5300256 chr14 164 20 5 189 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of DEGS2 expression and immune infiltrating cell level correlation result in HPV+ samples
DEGS2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of DEGS2 expression and immune infiltrating cell level correlation result in HPV+ samples
DEGS2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).