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HTLV1 Target gene Detail Information

> DRD3 Gene Search Result


Gene Information
Gene Name DRD3
Gene ID 1814
Gene Full Name dopamine receptor D3
Gene Alias D3DR; ETM1; FET1
Transcripts ENSG00000151577
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Uniport_ID P35462
HGNC ID HGNC:3024
VEGA ID OTTHUMG00000159334
OMIM ID 126451
String ID 9606.ENSP00000373169
Drugbank ID BE0000581
PharmGKB ID PA27479
Target gene [DRD3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004406 chr13 96 20 1 117 View
6011052 chr13 23 4 1 28 View
6019809 chr3 6 1 7 View
6022967 chr13 4 4 View
6028852 chr13 1 1 View
6030691 chr13 0 View
6030706 chr13 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of DRD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DRD3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of DRD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DRD3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of DRD3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
DRD3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).