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HIV Target gene Detail Information

> F5 Gene Search Result


Gene Information
Gene Name F5
Gene ID 2153
Gene Full Name coagulation factor V
Gene Alias FVL; PCCF; THPH2; RPRGL1
Transcripts ENSG00000198734
Virus HIV
Gene Type protein coding
HPA Location Info Golgi apparatus;Predicted to be secreted;
HPA Protein Class Info Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P12259
HGNC ID HGNC:3542
VEGA ID OTTHUMG00000034595
OMIM ID 612309
String ID 9606.ENSP00000356771
Drugbank ID BE0000041
PharmGKB ID PA159
FDA Approved Drug Avatrombopag;Eltrombopag;Lusutrombopag;Rivaroxaban;Tamoxifen
Target gene [F5] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000052 chr10 1373 124 75 1572 View
4003761 chr8 42 13 55 View
4004889 chr13 38 38 View
4005125 chr17 18 17 35 View
4005164 chr14 34 1 35 View
4005530 chr17 17 14 31 View
4005731 chr10 27 3 30 View
4006183 chr14 22 4 26 View
4008343 chr17 13 2 15 View
4008770 chr17 1 13 14 View
4008863 chr1 11 2 13 View
4010203 chr17 6 3 9 View
4011066 chr17 7 7 View
4011854 chr7 6 6 View
4012363 chr8 3 2 5 View
4012688 chr10 4 4 View
4014689 chr14 2 2 View
4015943 chr1 0 View
4016204 chr13 0 View
4016534 chr7 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of F5 expression and immune infiltrating cell level correlation result in HIV+ samples
F5 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of F5 expression and immune infiltrating cell level correlation result in HIV+ samples
F5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).