HTLV1 Target gene Detail Information

> FAM135A Gene Search Result

Gene Information

Gene Name	FAM135A
Gene ID	57579
Gene Full Name	family with sequence similarity 135 member A
Gene Alias	KIAA1411
Transcripts	ENSG00000082269
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9P2D6
HGNC ID	HGNC:21084
VEGA ID	OTTHUMG00000014991
String ID	9606.ENSP00000410768
PharmGKB ID	PA162386230

Target gene [FAM135A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002199	chr6	36	113	122	271	View
6007145	chr6	6	41	12	59	View
6010268	chr6	14	13	5	32	View
6020902	chr6		3	3	6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of FAM135A expression and immune infiltrating cell level correlation result in HTLV1+ samples
FAM135A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of FAM135A expression and immune infiltrating cell level correlation result in HTLV1+ samples
FAM135A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).