HTLV1 Target gene Detail Information

> FAM3D Gene Search Result

Gene Information

Gene Name	FAM3D
Gene ID	131177
Gene Full Name	family with sequence similarity 3 member D
Gene Alias	EF7; OIT1
Transcripts	ENSG00000198643
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q96BQ1
HGNC ID	HGNC:18665
VEGA ID	OTTHUMG00000159148
OMIM ID	608619
String ID	9606.ENSP00000351632
PharmGKB ID	PA38628

Target gene [FAM3D] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010200	chr3	28	4		32	View
6019977	chr3	4	3		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of FAM3D expression and immune infiltrating cell level correlation result in HTLV1+ samples
FAM3D expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of FAM3D expression and immune infiltrating cell level correlation result in HTLV1+ samples
FAM3D expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of FAM3D expression and immune infiltrating cell level correlation result in HTLV1+ samples
FAM3D expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).