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HBV Target gene Detail Information

> FGA Gene Search Result


Gene Information
Gene Name FGA
Gene ID 2243
Gene Full Name fibrinogen alpha chain
Gene Alias Fib2
Transcripts ENSG00000171560
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P02671
HGNC ID HGNC:3661
VEGA ID OTTHUMG00000150330
OMIM ID 134820
String ID 9606.ENSP00000306361
Drugbank ID BE0000538; BE0009672
PharmGKB ID PA429
Target gene [FGA] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1010527 chr4 12 12 View
1010528 chr4 12 12 View
1012217 chr4 7 7 View
1012218 chr4 7 7 View
1013589 chr4 4 1 5 View
1014592 chr4 1 2 3 View
1014593 chr4 3 3 View
1014594 chr4 3 3 View
1019827 chr4 0 View
1404619 chr4 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of FGA expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
FGA expression: Low -> High
Lollipop of FGA expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of FGA expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FGA expression and immune infiltrating cell level correlation result in HBV+ samples
FGA expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).