HIV Target gene Detail Information

> FUS Gene Search Result

Gene Information

Gene Name	FUS
Gene ID	2521
Gene Full Name	FUS RNA binding protein
Gene Alias	TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2
Transcripts	ENSG00000089280
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P35637
HGNC ID	HGNC:4010
VEGA ID	OTTHUMG00000132395
OMIM ID	137070
String ID	9606.ENSP00000254108
PharmGKB ID	PA28425

Target gene [FUS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001685	chr16	28	46	66	140	View
4002004	chr16	110	8		118	View
4011207	chr16	6	1		7	View
4013098	chr16	3		1	4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of FUS expression and immune infiltrating cell level correlation result in HIV+ samples
FUS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of FUS expression and immune infiltrating cell level correlation result in HIV+ samples
FUS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).