HBV Target gene Detail Information

> GRM5 Gene Search Result

Gene Information

Gene Name	GRM5
Gene ID	2915
Gene Full Name	glutamate metabotropic receptor 5
Gene Alias	mGlu5; GPRC1E; MGLUR5; PPP1R86
Transcripts	ENSG00000168959
Virus	HBV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P41594
HGNC ID	HGNC:4597
VEGA ID	OTTHUMG00000134306
OMIM ID	604102
String ID	9606.ENSP00000306138
Drugbank ID	BE0001192
PharmGKB ID	PA28994

Target gene [GRM5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011602	chr11	7	1		8	View
1015226	chr11		2		2	View
1403703	chr11		2		2	View
1403704	chr11	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of GRM5 expression and immune infiltrating cell level correlation result in HBV+ samples
GRM5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).