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HBV Target gene Detail Information

> HCN1 Gene Search Result


Gene Information
Gene Name HCN1
Gene ID 348980
Gene Full Name hyperpolarization activated cyclic nucleotide gated potassium channel 1
Gene Alias BCNG1; HAC-2; BCNG-1; EIEE24
Transcripts ENSG00000164588
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Voltage-gated ion channels
Uniport_ID O60741
HGNC ID HGNC:4845
VEGA ID OTTHUMG00000131155
OMIM ID 602780
String ID 9606.ENSP00000307342
PharmGKB ID PA77
Target gene [HCN1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007963 chr5 10 7 6 23 View
1007964 chr5 10 7 6 23 View
1016385 chr5 1 1 View
1019464 chr5 0 View
1019885 chr5 0 View
1400316 chr5 7 19 4 30 View
1401243 chr5 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HCN1 expression and immune infiltrating cell level correlation result in HBV+ samples
HCN1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).