EBV Target gene Detail Information

> HIGD2B Gene Search Result

Gene Information

Gene Name	HIGD2B
Gene ID	123346
Gene Full Name	HIG1 hypoxia inducible domain family member 2B
Gene Alias	HIGD2BP
Transcripts	ENSG00000175202
Virus	EBV
Gene Type	protein coding
HPA Location Info	Mitochondria;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q4VC39
HGNC ID	HGNC:26984
VEGA ID	OTTHUMG00000172776
String ID	9606.ENSP00000307951
PharmGKB ID	PA142671686

Target gene [HIGD2B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
3000958	chr15	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE102203 (GEO)	B-cell lymphoma	9	Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE45919 (GEO)	Infectious mononucleosis	24	Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO)	Infectious mononucleosis	17	Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO)	Multiple sclerosis	32	Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)

> Dataset: GSE102203
HeatMap of cell type fractions in all samples	Lollipop of HIGD2B expression and immune infiltrating cell level correlation result in EBV+ samples
HIGD2B expression: Low -> High

> Dataset: GSE45919
HeatMap of cell type fractions in all samples	Lollipop of HIGD2B expression and immune infiltrating cell level correlation result in EBV+ samples
HIGD2B expression: Low -> High

> Dataset: GSE85599
HeatMap of cell type fractions in all samples	Lollipop of HIGD2B expression and immune infiltrating cell level correlation result in EBV+ samples
HIGD2B expression: Low -> High

> Dataset: GSE58240
HeatMap of cell type fractions in all samples	Lollipop of HIGD2B expression and immune infiltrating cell level correlation result in EBV+ samples
HIGD2B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).