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EBV Target gene Detail Information

> HLA-A Gene Search Result


Gene Information
Gene Name HLA-A
Gene ID 3105
Gene Full Name major histocompatibility complex, class I, A
Gene Alias HLAA
Transcripts ENSG00000227715
Virus EBV
Gene Type protein coding
HPA Location Info Plasma membrane;Golgi apparatus;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P04439; P13746; P16188
HGNC ID HGNC:4931
VEGA ID OTTHUMG00000004793
OMIM ID 142800
String ID 9606.ENSP00000379873
Drugbank ID BE0003483; BE0003482
PharmGKB ID PA35055
FDA Approved Drug Carbamazepine;Ipilimumab
Target gene [HLA-A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
3200010 chr6 4719 2429 1711 8859 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE102203 (GEO) B-cell lymphoma 9 Plasmablastic lymphomas (EBV+)(6), Plasmablastic lymphomas (EBV-)(3)
GSE100458 (GEO) Burkitt lymphoma 14 Burkitt lyphoma cell line Akata(EBV+)(2),Burkitt lyphoma cell line Akata(EBV-)(2),Burkitt lyphoma cell line Awia(EBV+)(2),Burkitt lyphoma cell line Awia(EBV-)(2),Burkitt lyphoma cell line Eli(EBV+)(1),Burkitt lyphoma cell line Eli(EBV-)(1),Burkitt lyphoma cell line Mutu(EBV+)(2),Burkitt lyphoma cell line Mutu(EBV-)(2)
GSE42867 (GEO) Burkitt lymphoma 12 Burkitt lymphoma cell line Awia (EBV+)(12)
GSE135644 (GEO) Gastric carcinoma 10 Gastric adenocarcinoma cell line AGS (5), Gastric adenocarcinoma cell line AGS (EBV+)(5)
GSE45919 (GEO) Infectious mononucleosis 24 Infectious mononucleosis (IM)(EBV+)(3), Normal (9), Latent EBV (12)
GSE85599 (GEO) Infectious mononucleosis 17 Chronic active EBV infection (EBV+)(5), Acute infectious mononucleosis (EBV+)(6), Normal (6)
GSE58240 (GEO) Multiple sclerosis 32 Multiple sclerosis IFN-β treated (EBV+)(16), Multiple sclerosis untreated (EBV+)(16)
GSE12452 (GEO) Nasopharyngeal carcinoma 41 Nasopharyngeal carcinoma (EBV+)(31), Normal(10)

> Dataset: GSE102203

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE100458

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE42867

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE135644

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE45919

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE85599

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE58240

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High

> Dataset: GSE12452

HeatMap of cell type fractions in all samples Lollipop of HLA-A expression and immune infiltrating cell level correlation result in EBV+ samples
HLA-A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).