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HPV Target gene Detail Information

> HSD3B1 Gene Search Result


Gene Information
Gene Name HSD3B1
Gene ID 3283
Gene Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Gene Alias HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD
Transcripts ENSG00000203857
Virus HPV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;Nucleoli;Cytokinetic bridge;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P14060
HGNC ID HGNC:5217
VEGA ID OTTHUMG00000012525
OMIM ID 109715
String ID 9606.ENSP00000358421
Drugbank ID BE0000051
PharmGKB ID PA29486
Target gene [HSD3B1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5201195 chr1 3 2 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of HSD3B1 expression and immune infiltrating cell level correlation result in HPV+ samples
HSD3B1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).