HIV Target gene Detail Information

> HSH2D Gene Search Result

Gene Information

Gene Name	HSH2D
Gene ID	84941
Gene Full Name	hematopoietic SH2 domain containing
Gene Alias	ALX; HSH2
Transcripts	ENSG00000196684
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Cytosol;Focal adhesion sites;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q96JZ2
HGNC ID	HGNC:24920
VEGA ID	OTTHUMG00000182256
OMIM ID	608349
String ID	9606.ENSP00000482604
PharmGKB ID	PA134927763

Target gene [HSH2D] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004688	chr19	38	2		40	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HSH2D expression and immune infiltrating cell level correlation result in HIV+ samples
HSH2D expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HSH2D expression and immune infiltrating cell level correlation result in HIV+ samples
HSH2D expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).