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HPV Target gene Detail Information

> HTR1A Gene Search Result


Gene Information
Gene Name HTR1A
Gene ID 3350
Gene Full Name 5-hydroxytryptamine receptor 1A
Gene Alias G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
Transcripts ENSG00000178394
Virus HPV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P08908
HGNC ID HGNC:5286
VEGA ID OTTHUMG00000162279
OMIM ID 109760
String ID 9606.ENSP00000316244
Drugbank ID BE0000291; BE0004958
PharmGKB ID PA192
Target gene [HTR1A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200250 chr5 8 8 View
5201102 chr5 1 1 View
5201573 chr5 0 View
5404805 chr5 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of HTR1A expression and immune infiltrating cell level correlation result in HPV+ samples
HTR1A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).