HPV Target gene Detail Information

> HTR4 Gene Search Result

Gene Information

Gene Name	HTR4
Gene ID	3360
Gene Full Name	5-hydroxytryptamine receptor 4
Gene Alias	5-HT4; 5-HT4R
Transcripts	ENSG00000164270
Virus	HPV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q13639
HGNC ID	HGNC:5299
VEGA ID	OTTHUMG00000129931
OMIM ID	602164
String ID	9606.ENSP00000353915
Drugbank ID	BE0000084
PharmGKB ID	PA29557

Target gene [HTR4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5400643	chr5	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of HTR4 expression and immune infiltrating cell level correlation result in HPV+ samples
HTR4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).