HTLV1 Target gene Detail Information

> ICAM4 Gene Search Result

Gene Information

Gene Name	ICAM4
Gene ID	3386
Gene Full Name	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Gene Alias	LW; CD242
Transcripts	ENSG00000105371
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q14773
HGNC ID	HGNC:5347
VEGA ID	OTTHUMG00000180405
OMIM ID	614088
String ID	9606.ENSP00000342114
PharmGKB ID	PA29595

Target gene [ICAM4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000941	chr19	182	271	235	688	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ICAM4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICAM4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ICAM4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICAM4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ICAM4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICAM4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).