HTLV1 Target gene Detail Information

> IGFBP1 Gene Search Result

Gene Information

Gene Name	IGFBP1
Gene ID	3484
Gene Full Name	insulin like growth factor binding protein 1
Gene Alias	AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
Transcripts	ENSG00000146678
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Predicted to be secreted;
HPA Protein Class Info	Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P08833
HGNC ID	HGNC:5469
VEGA ID	OTTHUMG00000152343
OMIM ID	146730
String ID	9606.ENSP00000275525
Drugbank ID	BE0009530
PharmGKB ID	PA29703

Target gene [IGFBP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000926	chr7	609	46	51	706	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of IGFBP1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IGFBP1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of IGFBP1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IGFBP1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of IGFBP1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IGFBP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).