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HBV Target gene Detail Information

> INTS4 Gene Search Result


Gene Information
Gene Name INTS4
Gene ID 92105
Gene Full Name integrator complex subunit 4
Gene Alias INT4; MST093
Transcripts ENSG00000149262
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli rim;
HPA Protein Class Info Predicted intracellular proteins
Gene Function Oncogene
Uniport_ID Q96HW7
HGNC ID HGNC:25048
VEGA ID OTTHUMG00000166629
OMIM ID 611348
String ID 9606.ENSP00000434466
PharmGKB ID PA144596421
Target gene [INTS4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1008282 chr11 9 12 21 View
1402739 chr11 9 12 21 View
1404208 chr11 24 24 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of INTS4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
INTS4 expression: Low -> High
Lollipop of INTS4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of INTS4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of INTS4 expression and immune infiltrating cell level correlation result in HBV+ samples
INTS4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).