HPV Target gene Detail Information

> IRX1 Gene Search Result

Gene Information

Gene Name	IRX1
Gene ID	79192
Gene Full Name	iroquois homeobox 1
Gene Alias	IRX-5; IRXA1
Transcripts	ENSG00000170549
Virus	HPV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	P78414
HGNC ID	HGNC:14358
VEGA ID	OTTHUMG00000161632
OMIM ID	606197
String ID	9606.ENSP00000305244
PharmGKB ID	PA29924

Target gene [IRX1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402660	chr5	1			1	View
5402661	chr5	7	18	13	38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of IRX1 expression and immune infiltrating cell level correlation result in HPV+ samples
IRX1 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of IRX1 expression and immune infiltrating cell level correlation result in HPV+ samples
IRX1 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of IRX1 expression and immune infiltrating cell level correlation result in HPV+ samples
IRX1 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of IRX1 expression and immune infiltrating cell level correlation result in HPV+ samples
IRX1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).