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HPV Target gene Detail Information

> ISX Gene Search Result


Gene Information
Gene Name ISX
Gene ID 91464
Gene Full Name intestine specific homeobox
Gene Alias Pix-1; RAXLX
Transcripts ENSG00000175329
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoplasm;Nuclear bodies;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID Q2M1V0
HGNC ID HGNC:28084
VEGA ID OTTHUMG00000150962
OMIM ID 612019
String ID 9606.ENSP00000311492
PharmGKB ID PA147357909
Target gene [ISX] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5404817 chr22 98 6 1 105 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of ISX expression and immune infiltrating cell level correlation result in HPV+ samples
ISX expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).