HIV Target gene Detail Information

> ITGAL Gene Search Result

Gene Information

Gene Name	ITGAL
Gene ID	3683
Gene Full Name	integrin subunit alpha L
Gene Alias	CD11A; LFA-1; LFA1A
Transcripts	ENSG00000005844
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P20701
HGNC ID	HGNC:6148
VEGA ID	OTTHUMG00000176964
OMIM ID	153370
String ID	9606.ENSP00000349252
Drugbank ID	BE0000516
PharmGKB ID	PA29948

Target gene [ITGAL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000419	chr16	21	412	45	478	View
4005944	chr16	26	2		28	View
4007445	chr16	14	5		19	View
4007502	chr16	18	1		19	View
4009450	chr16	6	3	2	11	View
4011206	chr16	2	5		7	View
4011370	chr16	7			7	View
4012242	chr16	4	1		5	View
4013437	chr16	2	1		3	View
4013869	chr16	2		1	3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ITGAL expression and immune infiltrating cell level correlation result in HIV+ samples
ITGAL expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ITGAL expression and immune infiltrating cell level correlation result in HIV+ samples
ITGAL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).