HPV Target gene Detail Information

> IYD Gene Search Result

Gene Information

Gene Name	IYD
Gene ID	389434
Gene Full Name	iodotyrosine deiodinase
Gene Alias	TDH4; IYD-1; DEHAL1; C6orf71
Transcripts	ENSG00000009765
Virus	HPV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins
Uniport_ID	Q6PHW0
HGNC ID	HGNC:21071
VEGA ID	OTTHUMG00000016347
OMIM ID	612025
String ID	9606.ENSP00000229447
Drugbank ID	BE0004373
PharmGKB ID	PA162392352

Target gene [IYD] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5403678	chr6	2	2		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of IYD expression and immune infiltrating cell level correlation result in HPV+ samples
IYD expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662