HIV Target gene Detail Information

> KPNA6 Gene Search Result

Gene Information

Gene Name	KPNA6
Gene ID	23633
Gene Full Name	karyopherin subunit alpha 6
Gene Alias	IPOA7; KPNA7
Transcripts	ENSG00000025800
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	O60684
HGNC ID	HGNC:6399
VEGA ID	OTTHUMG00000004333
OMIM ID	610563
String ID	9606.ENSP00000362728
PharmGKB ID	PA30190

Target gene [KPNA6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002697	chr1	74	6	3	83	View
4003388	chr1	54	8		62	View
4007586	chr1	18			18	View
4014659	chr1	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KPNA6 expression and immune infiltrating cell level correlation result in HIV+ samples
KPNA6 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KPNA6 expression and immune infiltrating cell level correlation result in HIV+ samples
KPNA6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).