HIV Target gene Detail Information

> MAN1B1 Gene Search Result

Gene Information

Gene Name	MAN1B1
Gene ID	11253
Gene Full Name	mannosidase alpha class 1B member 1
Gene Alias	MRT15; ERMAN1; ERManI; MANA-ER
Transcripts	ENSG00000177239
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9UKM7
HGNC ID	HGNC:6823
VEGA ID	OTTHUMG00000020978
OMIM ID	604346
String ID	9606.ENSP00000360645
Drugbank ID	BE0001414
PharmGKB ID	PA30572

Target gene [MAN1B1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001036	chr9	225	2		227	View
4003983	chr9	48	2	1	51	View
4004904	chr9	38			38	View
4009609	chr9	11			11	View
4009993	chr9	10			10	View
4012374	chr9	5			5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAN1B1 expression and immune infiltrating cell level correlation result in HIV+ samples
MAN1B1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAN1B1 expression and immune infiltrating cell level correlation result in HIV+ samples
MAN1B1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).