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HBV Target gene Detail Information

> MAP2K1 Gene Search Result


Gene Information
Gene Name MAP2K1
Gene ID 5604
Gene Full Name mitogen-activated protein kinase kinase 1
Gene Alias CFC3; MEK1; MKK1; MAPKK1; PRKMK1
Transcripts ENSG00000169032
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID Q02750
HGNC ID HGNC:6840
VEGA ID OTTHUMG00000133196
OMIM ID 176872
String ID 9606.ENSP00000302486
Drugbank ID BE0000870
Drug (Cytoscape Annotation) Trametinib;Cobimetinib;Sunitinib Malate;Bosutinib;Dasatinib
PharmGKB ID PA30584
FDA Approved Drug Binimetinib
Target gene [MAP2K1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003623 chr15 7 109 5 121 View
1006889 chr15 15 12 6 33 View
1018371 chr15 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MAP2K1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MAP2K1 expression: Low -> High
Lollipop of MAP2K1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MAP2K1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MAP2K1 expression and immune infiltrating cell level correlation result in HBV+ samples
MAP2K1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).