HIV Target gene Detail Information

> MAP3K5 Gene Search Result

Gene Information

Gene Name	MAP3K5
Gene ID	4217
Gene Full Name	mitogen-activated protein kinase kinase kinase 5
Gene Alias	ASK1; MEKK5; MAPKKK5
Transcripts	ENSG00000197442
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q99683
HGNC ID	HGNC:6857
VEGA ID	OTTHUMG00000015647
OMIM ID	602448
String ID	9606.ENSP00000351908
PharmGKB ID	PA30601

Target gene [MAP3K5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007628	chr6	3	15		18	View
4014026	chr6	3			3	View
4015138	chr6	1			1	View
4016038	chr6				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MAP3K5 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K5 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MAP3K5 expression and immune infiltrating cell level correlation result in HIV+ samples
MAP3K5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).