HIV Target gene Detail Information

> MBD4 Gene Search Result

Gene Information

Gene Name	MBD4
Gene ID	8930
Gene Full Name	methyl-CpG binding domain 4, DNA glycosylase
Gene Alias	MED1
Transcripts	ENSG00000129071
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O95243
HGNC ID	HGNC:6919
VEGA ID	OTTHUMG00000159463
OMIM ID	603574
String ID	9606.ENSP00000249910
PharmGKB ID	PA30663

Target gene [MBD4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004877	chr3	24	14		38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MBD4 expression and immune infiltrating cell level correlation result in HIV+ samples
MBD4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MBD4 expression and immune infiltrating cell level correlation result in HIV+ samples
MBD4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).