HIV Target gene Detail Information

> MCL1 Gene Search Result

Gene Information

Gene Name	MCL1
Gene ID	4170
Gene Full Name	MCL1, BCL2 family apoptosis regulator
Gene Alias	TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
Transcripts	ENSG00000143384
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Oncogene
Uniport_ID	Q07820
HGNC ID	HGNC:6943
VEGA ID	OTTHUMG00000034867
OMIM ID	159552
String ID	9606.ENSP00000358022
Drugbank ID	BE0003511
PharmGKB ID	PA30688

Target gene [MCL1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002705	chr1	61	22		83	View
4009554	chr2	5	5	1	11	View
4010311	chr2	9			9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of MCL1 expression and immune infiltrating cell level correlation result in HIV+ samples
MCL1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of MCL1 expression and immune infiltrating cell level correlation result in HIV+ samples
MCL1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).