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HBV Target gene Detail Information

> MET Gene Search Result


Gene Information
Gene Name MET
Gene ID 4233
Gene Full Name MET proto-oncogene, receptor tyrosine kinase
Gene Alias HGFR; AUTS9; RCCP2; c-Met; DFNB97
Transcripts ENSG00000105976
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Plasma membrane;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID P08581
HGNC ID HGNC:7029
VEGA ID OTTHUMG00000023299
OMIM ID 164860
String ID 9606.ENSP00000317272
Drugbank ID BE0000915
Drug (Cytoscape Annotation) Axitinib;Crizotinib
PharmGKB ID PA30763
FDA Approved Drug Cabozantinib;Crizotinib;Capmatinib
Target gene [MET] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1009612 chr7 1 14 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MET expression and immune infiltrating cell level correlation result in HBV+ samples
MET expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).