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HBV Target gene Detail Information

> MTDH Gene Search Result


Gene Information
Gene Name MTDH
Gene ID 92140
Gene Full Name metadherin
Gene Alias 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
Transcripts ENSG00000147649
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
Gene Function Oncogene
Uniport_ID Q86UE4
HGNC ID HGNC:29608
VEGA ID OTTHUMG00000164692
OMIM ID 610323
String ID 9606.ENSP00000338235
PharmGKB ID PA142671307
Target gene [MTDH] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006476 chr8 35 3 38 View
1400389 chr8 15 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MTDH expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MTDH expression: Low -> High
Lollipop of MTDH expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MTDH expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MTDH expression and immune infiltrating cell level correlation result in HBV+ samples
MTDH expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).