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HPV Target gene Detail Information

> MTNR1B Gene Search Result


Gene Information
Gene Name MTNR1B
Gene ID 4544
Gene Full Name melatonin receptor 1B
Gene Alias MT2; FGQTL2; MEL-1B-R
Transcripts ENSG00000134640
Virus HPV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P49286
HGNC ID HGNC:7464
VEGA ID OTTHUMG00000167364
OMIM ID 600804
String ID 9606.ENSP00000257068
Drugbank ID BE0000327
PharmGKB ID PA31268
Target gene [MTNR1B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5404010 chr11 2 1 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of MTNR1B expression and immune infiltrating cell level correlation result in HPV+ samples
MTNR1B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).