HBV Target gene Detail Information

> NR3C2 Gene Search Result

Gene Information

Gene Name	NR3C2
Gene ID	4306
Gene Full Name	nuclear receptor subfamily 3 group C member 2
Gene Alias	MR; MCR; MLR; NR3C2VIT
Transcripts	ENSG00000151623
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Uniport_ID	P08235
HGNC ID	HGNC:7979
VEGA ID	OTTHUMG00000161455
OMIM ID	600983
String ID	9606.ENSP00000350815
Drugbank ID	BE0000668
Drug (Cytoscape Annotation)	Dexamethasone
PharmGKB ID	PA242

Target gene [NR3C2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004720	chr4	52	13	6	71	View
1006128	chr4	43			43	View
1008654	chr4	8	12		20	View
1010950	chr4	4		6	10	View
1011386	chr4	4	5		9	View
1011528	chr4	9			9	View
1012965	chr4	1	1	4	6	View
1015064	chr4	3			3	View
1400867	chr4	4		6	10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of NR3C2 expression and immune infiltrating cell level correlation result in HBV+ samples
NR3C2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).