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HBV Target gene Detail Information

> PDE3A Gene Search Result


Gene Information
Gene Name PDE3A
Gene ID 5139
Gene Full Name phosphodiesterase 3A
Gene Alias HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A
Transcripts ENSG00000172572
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins
Uniport_ID Q14432
HGNC ID HGNC:8778
VEGA ID OTTHUMG00000168962
OMIM ID 123805
String ID 9606.ENSP00000351957
Drugbank ID BE0000436; BE0004922
PharmGKB ID PA33126
Target gene [PDE3A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004767 chr12 52 16 2 70 View
1005282 chr12 17 5 35 57 View
1005553 chr12 17 3 32 52 View
1006801 chr12 21 12 1 34 View
1008647 chr12 18 1 1 20 View
1009329 chr12 13 3 16 View
1009349 chr12 13 3 16 View
1009358 chr12 13 3 16 View
1009362 chr12 13 3 16 View
1009390 chr12 13 3 16 View
1009404 chr12 13 3 16 View
1013264 chr12 1 4 5 View
1013919 chr12 3 1 4 View
1013983 chr12 3 1 4 View
1014017 chr12 3 1 4 View
1014030 chr12 3 1 4 View
1014093 chr12 3 1 4 View
1014111 chr12 3 1 4 View
1014120 chr12 3 1 4 View
1014133 chr12 3 1 4 View
1019813 chr12 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PDE3A expression and immune infiltrating cell level correlation result in HBV+ samples
PDE3A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).